1. Glucokinase and hexokinase perform the same enzymatic functionyet their role in carbohydrate metabolism / homeostasis issubstantially different. a. Describe their cellular distribution /locations, functions, enzyme kenetics, and their regulation ofeach. b. Describe how each contributes to glucose homeostasis. c.Describe how insulin and glucagon may regulate these two enzymes.2. The liver is centrally involved in the regulation of bloodglucose levels. a. Describe what and how the liver contributes toglucose levels in both fed and fasted states b. Describe themolecular sources of substrates for glucose production. It isimportant to discuss the cellular source of these molecules as wellas the physiological conditions in which they would be produced. c.Explain how and why blood glucose concentrations becomedis-regulated during both fed and fasted states with type IIdiabetes.
