1. In what part of ahepatocyte would a drug interaction involving CYP enzymes mostlikely occur?
A. Endoplasmic reticulum
B. Lysosomes
C. Golgi apparatus
D.Outer cell membrane
E. Nucleus membrane
2. Simvastatin is at higher risk of initiating rhabdomyolysiswhen co-administered with all except the following?
A. Anti-IL-6 therapy (tocilizumab)
B. Strong CYP3A4 inhibitors
C. Grapefruit juice
D. Mechanism-based CYP3A4 inhibitors
E. Hepatocyte OATP inhibitors
