1)
methotrexate is an inhibitor for the folate cycle which is
important in both purine and pyrimidine...
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Biology
1)methotrexate is an inhibitor for the folate cycle which isimportant in both purine and pyrimidine synthesis. Where on eachpathway does folate play a crucial role? How is this medicationused as a chemotherapy?
2)Irritable bowel syndrome is a medical issue that results from adysfunction in bile acid. Please explain normal pathways of bileacid in the body and then explain the dysfunctions related to bileacid in irritable bowel syndrome. Lastly how is this IBS medicallymanaged?
3)A long distance runner is preparing to complete their firstmarathon. She is concerned about her nutrition before and after herrace. What types of foods would be beneficial for an athlete priorto a long distance race? What pathways would be most active duringthe beginning of the race? At the end of the race? What would theeffect be if she decided not to eat prior to the race or if she atefoods that were contraindicated?
4)How might a hypothetical disease causing the deacetylation ofhistones associated with the gene expressing malate dehydrogenaseaffect the respiratory chain? What symptoms might this diseasecause and why?
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Folate derivatives participate in the biosynthesis of both purines and pyrimidines Formyl folate is required for two of the steps in the biosynthesis of inosine monophosphate the precursor to GMP and AMP Methylenetetrahydrofolate donates the C1 center required for the biosynthesis of dTMP 2deoxythymidine5phosphate from dUMP 2deoxyuridine5phosphate The conversion is catalyzed by thymidylate synthase Methotrexate is an antimetabolite of the antifolate type It is thought to affect cancer and rheumatoid arthritis by two different pathways For cancer methotrexate competitively inhibits dihydrofolate reductase DHFR an enzyme that
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