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1. name at least four mechanisms that may hold a hydrogel together without covalent bonds? In...

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Biology

1. name at least four mechanisms that may hold a hydrogeltogether without covalent bonds? In other words, physicalcrosslinking?

2. provide 2 examples on how pH sensitive polymers/hydrogels maybe useful in biomedical field?

Please provide detain explanation how pH changed in human bodyand how the polymer in response to such change?

3. Why do think we need to incorporate cell instructive peptide(such as RGD) into PEG hydrogel

4. What are the two major degradable strategy in hydrogel?

What are the chemical components of normal enzymatic degradablecrosslinker? Do you know why?

Answer & Explanation Solved by verified expert
4.3 Ratings (757 Votes)
Answer 1A hydrogel is simply a hydrophilicpolymeric network crosslinked in some fashion to produce anelastic structureThus any technique which can be used to create acrosslinked polymer can be used to produce a hydrogelCopolymerizationcrosslinking freeradical polymerizations arecommonly used to produce hydrogels by reacting hydrophilic monomerswith multifunctional crosslinkersMechanisms that may hold ahydrogel together without covalent bonds area chain entanglements bHbonds c affinity recognition d ionic interactions eheterodimer complexation f stereocomplex formation gcrystallite formationAny of the various polymerization techniquescan be used to form gels including bulk solution and suspensionpolymerizationPolymerization by irradiation is anew technique for hydrogel prepration In this method ionizing highenergy radiation like gamma rays and electron beams has been usedas an initiator to prepare the hydrogels of unsaturated compoundsThe irradiation of aqueous polymer solution results in theformation of radicals on the polymer chains Also radiolysis ofwater molecules results in the formation of hydroxyl radicalswhich also attack the polymer chains resulting in the formation ofmacroradicalsAnswer 2All the pHsensitive polymerscontain pendant acidic eg carboxylic and sulfonic acids orbasic eg ammonium salts groups that    See Answer
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