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1. Which checkpoint and phase of the cell cycle is the expression of BRCA1 and BRCA2...

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Biology

1. Which checkpoint and phase of the cell cycle is theexpression of BRCA1 and BRCA2 the greatest? What is the function ofBRCA1 and why would it make sense that its expression is high atthe checkpoint/phase of the cell cycle?

2. Outline the two parts of the eukaryotic cell cycle anddescribe the three main checkpoints in cell cycle regulation.

*PLEASE ANSWER QUESTIONS AS SIMPLY AS POSSIBLE. I AM IN A BASICGENETICS COURSE*

*The answers should be completed in a paragraph or less for eachquestion. Please and thank you!*

Answer & Explanation Solved by verified expert
4.0 Ratings (813 Votes)
1 BRCA1 has a bellshaped pattern of expression during the cell cycle Note that active BRCA1 is tagged with a phosphate group in a process known as phosphorylation The expression of BRCA1 slowly starts increasing at S phase and peaks at the G2 phase and deceases at mitosis As far as the checkpoint is considered the increase of BRCA1 expression starts from the DNA replication checkpoint that is G2 checkpoint BRCA2 is highly expressed in the S phase of the cell    See Answer
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