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10 In the figure to the left a shows how the normal regulatory gene produces a protein pink oval that regulates the gene for active protein Based on the figure this protein is a transcription factor Assume that the gene for active protein is the CYP1A2 gene which codes for the active protein CYP1A2 purple circle CYP1A2 is involved in the main route of caffeine metabolism but other routes are possible yet slower to metabolize caffeine Those that metabolise caffeine fast do not feel the jittery effects after drinking coffee those that metabolize caffeine slowly report feeling jittery after drinking coffee r functional wt r allele in panel a and c a functional wt a allele in panel a and b r mutant rallele in panel b and d a mutant a allele in panel c and d a Normal b Mutation in the gene that encodes the regulatory protein c Mutation in the gene that encodes the structural protein d Mutation in both genes Figure 6 15 hod Regulatory gene Gene for active protein g rt to Genetic Analysis Tenth Edition 2012 WH Freeman and Company mim Anar a min mim nim a Nonfunctional regulatory protein sent une sim AVY A Auran m m A note about genotype notations The genotype r r means the person has an r allele on one chromosome and the r allele on the homologous chromosome A semi colon in the genotype indicates two different loci genes for example r r a a The r genotype is for the r locus and the a genotype is for the a locus Predict what the observed phenotypes will be for the following genotypes a r r a a

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