17. Which histone is required to compact the “beads on a stringâ€chromatin into higher-order chromatin structures such as the 30 nmfiber?
18. Certain lysine amino acids (K’s) in the core histone tailcan be acetylated. How would this chemical modification of thenucleosome affect the transcription of a gene?
19. Certain protein/protein complexes do not bind DNA, butregulate processes such as transcription and replication. Theseproteins can associate with the chromatin by recognizing chemicalmodifications in the core histone tails of the nucleosome. Thisprocess represents the “histone codeâ€. Separately, a protein thatfolds into its three-dimensional functional structures can havedifferent domains with different functions. Assume that a certainprotein that increases transcription does not recognize a specificDNA sequence, but rather associates with acetylated lysine aminoacids in the histone tails. What domain in this protein would allowit to associate with these acetylated lysine amino acids?
