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1.The TCA cycle in a particular tissue has been inhibited by fluoroacetate. However, it is not...

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Biology

1.The TCA cycle in a particular tissue has been inhibited byfluoroacetate. However, it is not the fluoroacetate that isresponsible for the inhibition. It gets converted to anothermolecule that enters the TCA cycle and is transformed into theinhibitor.

a) Propose the inhibitor molecule and mechanistically show theconversion of fluoroacetate to the inhibitor.

b) Indicate at what step fluoroacetate ultimately inhibits theTCA cycle.

c) Explain why you think fluoroacetate acts as an inhibitor ofthis enzyme? Your answer should include some sort of mechanisticexplanation.

d) What difference in the concentration of each TCA cyclemetabolite would you expect, compared with a normal uninhibitedtissue? List each metabolite and indicate the effect on itsconcentration.

Answer & Explanation Solved by verified expert
3.9 Ratings (700 Votes)
1 TCA cycle in particular is inhibited by fluoroacetateFluoroacetate is a compound the binds to theCoenzyme A of the Krebs cycle to form Floroacetyl CoA which in turnforms fluorocitrate instead of forming citrate This fluorocitrateis not able to bind to aconitase    See Answer
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