2. Calculate the theoretical yield (g) of Zybanhydrochloride
3. Write out the mechanism for the a-bromination of 1(m-chloropropiophenone).
4. Step 2 is a substitution of bromine by t-butylamine. Whattype of substitution is occurring: SN1 or SN2 Explain based on thereaction’s substrate and solvent.
5. The reaction mixture from the substitution step 2 isextracted with diethylether to isolate the product. State layer(organic or aqueous) in which each of the following compounds willbe present in the highest concentration. a. NMP___________________b. Excess t-butylamine__________________ c.HBr______________________ d. Zyban free base (compound3a____________________
6. Why are the ether extracts combined then extracted with waterat the end of Step 2?
7. The HCl solution used in the final step was made by mixing 20mL concentrated HCl (12.0 M) with 100 mL isopropyl alcohol. Whywasn’t an aqueous HCL solution used for this part of thesynthesis?
8. Describe the pharmacology of Zyban.
