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  3. 2. you have learned many different mechanisms that

2. You have learned MANY different mechanisms that can lead to cancer development. One of these...

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Biology

2. You have learned MANY different mechanisms that can lead tocancer development. One of these mechanisms involves changes inepigenetics during tumor initiation and progression.

A. HDAC proteins (a class of eraser proteins) are oftenoverexpressed in cancer cells. Provide a 2-4 sentence explanationfor how HDAC overexpression could promote tumor growth (includewhat the abbreviation HDAC stands for).

B. If HDAC overexpression favors tumor initiation, explain onepotential problem of HDAC underexpression that could result intumor growth.

C. A few anti-cancer drugs are currently on the market thatinhibit HDACs. Given what you know about HDACs and cancer, providea brief molecular explanation about how these drugs may work. Wouldyou anticipate there to be any side effects? If so, provide anexample with a brief explanation.

Answer & Explanation Solved by verified expert
4.0 Ratings (612 Votes)
Epigenetic modifications These modifications alter the recruitment of RNA polymerase to the gene locus by changing the compactness of the chromatin Ex Histone modifications and DNA methylation Histones are positively charged basic proteins that bind to negatively charged DNA Factors    See Answer
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