2. You have learned MANY different mechanisms that can lead tocancer development. One of these mechanisms involves changes inepigenetics during tumor initiation and progression.
A. HDAC proteins (a class of eraser proteins) are oftenoverexpressed in cancer cells. Provide a 2-4 sentence explanationfor how HDAC overexpression could promote tumor growth (includewhat the abbreviation HDAC stands for).
B. If HDAC overexpression favors tumor initiation, explain onepotential problem of HDAC underexpression that could result intumor growth.
C. A few anti-cancer drugs are currently on the market thatinhibit HDACs. Given what you know about HDACs and cancer, providea brief molecular explanation about how these drugs may work. Wouldyou anticipate there to be any side effects? If so, provide anexample with a brief explanation.
