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29. A genetic testing company offers expanded carrier screening. Amongst the conditions they test for, they...

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Biology

29. A genetic testing company offers expanded carrier screening.Amongst the conditions they test for, they provide the followinginformation regarding the carrier frequency and testing sensitivityfor cystic fibrosis (CF) in different populations.

Ethnicity

Carrier frequency

Testing sensitivity

African American

1 in 61

97%

Ashkenazi Jewish

1 in 29

93%

Asian

1 in 88

98%

Caucasian

1 in 28

92%

A couple consisting of a Caucasian man and an Asian woman areinterested in doing this expanded carrier screening test.

  1. Assuming there are no known people affected with CF in eitherof their families, what are the baseline (i.e. before testing)chances of this couple having a child affected with CF?
  1. The woman does testing first, and she is found to be a CFcarrier. Taking this finding into account, what are the updatedchances of this couple having a child affected with CF?
  1. The man does testing, and results show he has not been detectedas a carrier. Taking both the man’s and the woman’s testing resultsinto account, what are their updated chances of having a child withCF?

Answer & Explanation Solved by verified expert
4.0 Ratings (631 Votes)
To have cystic fibrosis a child must inherit one copy of thecystic fibrosis transmembrane conductance regulator CFTR genemutation from each    See Answer
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