66. Describe the role of force fields in the approach to
identify a protein that binds...
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Biology
66. Describe the role of force fields in the approach toidentify a protein that binds influenza hemagglutinin.
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Influenza virus belongs to a wide range of enveloped viruses The viral envelope contains two spike proteins hemagglutinin HA and neuraminidase NA as well as the proton channel M2 The major spike protein hemagglutinin binds sialic acid slag of glycoproteins and glycolipids with segregation constants in the millimolar rangeThe crystal structure of the viral HA bound to its cellular receptor sialic acid SA shows that the receptorbinding domain is located in the HA1 subunit The first
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