A 0.01 % solution of paracetamol API was analysed by HPLC giving
a peak at 4.35...
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A 0.01 % solution of paracetamol API was analysed by HPLC givinga peak at 4.35 minutes from a c18 5 micron column. The peak area is159785643. The peak area of a 0.05 % paracetamol standard is80045687. Calculate the % assay for paracetamol API. Do you thinkthis would comply with release specification of an active drugsubstance?
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Ans The Assay in HPLC analysis can be calculated as per the below formula Conc of StandardPeak Area of the
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