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A 2-year-old girl is brought to your clinic. Developmentally normal, her parents had noticed her to...

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Question

Medical Sciences

  • A 2-year-old girl is brought to your clinic.Developmentally normal, her parents had noticed her to be bruisingeasily.

    Coagulation tests show:

Test

Patient

Reference Range

PT

13s

11-14s

APTT

105s

23-35s

Fibrinogen (Clauss)

2.7g/L

1.5-4.0g/L

Thrombin Time

13s

10-13s

1. What additional questions might you ask theparents?
2. Briefly outline how you would investigate the clottingabnormalities.

3. What are the possible explanations for theseresults?

The prolonged PT and APTT correct in a mix with normalplasma.

A 10-day-old baby, previously well, breast fed and bornat home is found by his parents unconscious and bleeding from mouthand gums. The only history of note is that the mother had had amajor post-partum haemorrhage and had required emergency admissionto hospital.

A coagulation screen shows:

Test

Patient

Reference Range

PT

102s

11-14s

APTT

>120s

23-35s

Fibrinogen (Clauss)

1.9g/L

1.5-4.0g/L

Thrombin Time

13s

10-13s

1. What is the most likely diagnosis?
​​​​​​​2. How would you confirm this?

3. Why does this occur?

Answer & Explanation Solved by verified expert
3.7 Ratings (329 Votes)
1A 2yrs old girl with chief complains of easy bruising 1st history taking is utmost important since already coagulation study is givenit will further guide us to the probable diagnosis only APTT prolongedothers being normalAll these guide us that it is most probably a clotting disorderHemophiliaA hemophiliaB von willibrand disease Questions that we will ask the parents duration of symptoms Any family history of clotting disorders Any spontaneous    See Answer
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