A 37-year-old man is diagnosed with Philadelphiachromosome-positive (Ph+) chronic myelogenous leukemia (CML).
a. What is the molecular mechanism that makes this kind ofcancer?(1/2 page)
b. What is the first-line treatment for CML and what is therationale for this pharmacotherapy?(1/4 page)
c. What are the mechanisms of resistance to imatinibpharmacotherapy of CML?(1/4 page)
d. What other cancers and diseases are effectively treated withimatinib?(1/4 page)
e. What are the common and important side effects of therapywith imatinib(1/4 page)
