A 65 kg, 34-year-old epileptic patient is receiving 300 mgphenytoin daily for epilepsy. Her albumin is 2.4 g/dL andcreatinine clearance is 79 ml/min. After three weeks of therapy,the total phenytoin concentration is 8.5 mg/L. What is therecommended new phenytoin dose to achieve a therapeuticconcentration of 10 - 20 mg/L?
