A cell is defective in succinate dehydrogenase. Will its HIF-1
be hydroxylated by PH-2 under this...
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Biology
A cell is defective in succinate dehydrogenase. Will its HIF-1be hydroxylated by PH-2 under this condition? Justify.
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Hypoxia inhibitory factor or HIF is composed of HIF1 alpha and HIF 1 beta and is involved in low oxygen condition or hypoxia HIF 1 alpha is degraded in cells under high oxygen concentration However when oxygen levels decline it accumulates in the cell HIF 1 beta levels are constant When oxygen levels are normal normoxia20 oxygen
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