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a. Describe the kinase cascade that transmits signals down from the activated Ras protein. b. Platelet derived...

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Medical Sciences

a. Describe the kinase cascade that transmits signals down fromthe activated Ras protein.

b. Platelet derived growth factor (PDGF) is a dimer of twopolypeptide chains. How would PDGF monomers affect signaling by thePDGF receptor?

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MAP Kinase Pathways All Raslinked RTKs in mammalian cells appear to utilize a highly conserved signaltransduction pathway in which the signal induced by ligand binding is carried via GRB2 and Sos to Ras leading to its activation Activated Ras then induces a kinase cascade that culminates in activation of MAP kinase This serinethreonine kinase which can translocate into the nucleus phosphorylates many different proteins including transcription factors that regulate expression of important cellcycle and differentiationspecific proteins In this section we first examine the    See Answer
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