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Aconitase is an enzyme that displays moonlighting behavior dependent on cytosolic [iron]. When the concentration of...

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Medical Sciences

Aconitase is an enzyme that displays moonlighting behaviordependent on cytosolic [iron]. When the concentration of iron islow, aconitase undergoes a shift towards mRNA binding activities.Please speculate as to the structural basis for this[iron]-dependent activity switch. What is the role and function ofthe iron-sulfur cluster in aconitase? What is the physiologicrelevance of aconistase’s functional dependence on [iron]?

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Answer Aconitase is an ironsulfur protein that is involved in the first step of the tricarboxylic acid TCA cycle and oxidative inactivation of its ironsulfur cluster by superoxide leads to iron toxicity and peroxide production Two aconitase isozymes are present in mammalian cells 1 maconitase the mitochondrial enzyme that functions in the TCA cycle and also essential for mtDNA maintenance 2 caconitaseIRP1 the cytosolic enzyme plays a role in the regulation of iron metabolism In mammalian cell IRP1Iron regulatory protein 1 switches    See Answer
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