Angiogenesis is an essential property of many solid tumors, andthe target of several anticancer drugs. One clinically importantangiogenic pathway involves vascular endothelial growth factor(VEGF) and its cognate receptors.
a) What is VEGF and how is it important in tumor growth andsurvival?
b). What agents target the VEGF pathway and what are theirmechanisms of action?
c.) What kinds of tumors are effectively treated with agentsthat target the VEGF pathway?
d) What are the important toxicities of the agents that targetthe VEGF pathway?
