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As part of a pathophysiology lecture in a fourth year course, you are informed that two...

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Medical Sciences

As part of a pathophysiology lecture in a fourth year course,you are informed that two different types of G-protein coupledreceptors are expressed on a human organ system. The activation ofreceptor-1 (R-1) causes an elevation in cyclic adenosinemonophosphate (cAMP) levels in the cells. While the activation ofreceptor-2 (R-2) causes an inhibition in the rise of cAMP levels inthe same cells.

Q1. Which G-protein alpha subunit is most likely associated withR-1 and R-2? 2 points R-1 = Q2.

You are further informed that activation of R-1 causesrelaxation of smooth muscles in the organ expressing thesereceptors.

What do you think could be the possible effect of R-2activation? 1 point

Q3. If the pathophysiology (clinical problem) in patients isexcessive muscle contraction and constriction of the tissue, howcan you target these two receptors to correct the underlyingdisorder? Note: Think in terms of agonist/antagonist for receptorsR-1 and R-2. 2 points

Answer & Explanation Solved by verified expert
4.4 Ratings (660 Votes)
Q1ans Many membrane bound receptor produce response through the activation of G protein G protein have mainly three subunit iealpha betagamma G protein is in active state whenGTP bounded    See Answer
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