Attachment of myelin to the surface of some neurons occurs viathe interactions of transmembrane adhesion molecules expressed onthe myelin membrane with receptors on the target axons. Severalhuman peripheral neuropathies are associated with mutations ingenes encoding theses myelin-associated proteins that disruptmyelin-axon attachment, (1) Explain the symptoms this lossof peripheral myelination might be expected cause and why, giventhe function of myelin in the nervous system. (2) Propose ahypothesis to explain why only peripheral and not central nervoussystem symptoms are observed in these diseases.
