Benzodiazepines are positive allosteric modulators at the GABA-Areceptor. a) Describe how positive allosteric modulators affectreceptor function. b) Discuss the mechanism of action ofbenzodiazepines and their effect on central nervous system (CNS)activity. c) GABA is also an agonist at GABA-B receptors,which are G protein coupled receptors that couple to Gi. Explainthe signalling pathways that will be activated when GABA binds tothe GABA-B receptor.
