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Biochemistry Question You have developed a new chemotherapeutic that acts to competitively inhibit a kinase you are...

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Biology

Biochemistry Question

You have developed a new chemotherapeutic that acts tocompetitively inhibit a kinase you are targeting in cancer cells.In clinical trials, the drug is effective in killing the cancercells, however patients also develop hemolytic anemia. Afterfurther testing you discover that the drug is also competitivelyinhibiting Phosphofructokinase-1 (PFK-1).

1. What effect would the drug have on the KM andVmax of PFK-1?

2. Why would the inhibition of PFK-1 result in the developmentof hemolytic anemia? Explain.

Answer & Explanation Solved by verified expert
4.5 Ratings (885 Votes)
1 Km of PFK1 will increase and Vmax will be constant In competitive inhibition both the substrate and inhibitor has same molecular comparability so binding depends upon the    See Answer
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