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Briefly explain why you might expect neoplastic cells in a primary tumor to be more heterogeneous...

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Medical Sciences

Briefly explain why you might expect neoplastic cells in aprimary tumor to be more heterogeneous to each other (especially interms of mutations) as compared to the neoplastic cells in ametastasis.

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Ans The types of variability usually meant by the term tumor heterogeneity are cellular differences within a single neoplasm Tumors are architecturally complex differing regionally in vasculature host infiltrates connective tissue components and other characteristics which can alter the phenotype of otherwise identical cells Marked differences in the proliferation behavior of tumor cells within a single cancer are common place Some    See Answer
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