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Clindamycin binds to the 50S ribosomal subunit of bacteria. Using this information, respond to the following: a....

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Biology

Clindamycin binds to the 50S ribosomal subunit of bacteria.Using this information, respond to the following:

a. Referring to the 5 modes or mechanisms of actions ofantibiotics, which one applies to clindamycin?

b. Is this a broad or narrow spectrum antibacterial agent?Explain

c. Does clindamycin have selective toxicity for bacteria?Explain

Answer & Explanation Solved by verified expert
3.9 Ratings (440 Votes)
a Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria This agent disrupts protein synthesis by interfering with the transpeptidation reaction which thereby inhibits early chain elongation Clindamycin may potentiate the opsonization and phagocytosis of bacteria even at subinhibitory concentrations By disrupting bacterial protein synthesis clindamycin causes changes in the cell wall surface which decreases adherence of bacteria to host cells and increases intracellular    See Answer
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