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Consider the brain areas and connections pictured in the simplified basal ganglia circuit. Parkinson’s disease results...

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Medical Sciences

Consider the brain areas and connections pictured in thesimplified basal ganglia circuit. Parkinson’s disease results fromthe degeneration of dopamine neurons in the substantia nigra parscompacta (SNc). Dopamine can inhibit or excite neurons in theputamen, a sub-division of the striatum. Describe how this damagecauses a chain of effects on activity in other basal ganglia areasand the structures they ultimately output to, and how this resultsin hypokinesia (reduced movements) in two different ways. Make sureto refer differentially to the ‘direct’ and ‘indirect’pathways.

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Parkinsons is a condition which causes the gradual loss of dopamineproducing brain cells of the substantia nigra Dopamine is a neurotransmitter which sends impulsesloss of dopamine causes slowing of impulses due to which slow movements occurs that is hypokinesia N Neurons in substantia nigra pars compacta produce dopaminethat transmits signals from the substantia nigra to other parts of the brain    See Answer
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