Consider the following naturally occurring forms of Hb. A. HbS(sickle-cell Hb): substitutes a V for a E on the surface B. HbCowtown: eliminates an ion pair involved in T-state stabilizationC. Hb Memphis: substitutes one uncharged polar residue for anotherof similar size on the surface D. Hb Bibba: substitutes a P for a Linvolved in an a helix E. Hb Milwaukee: substitutes a E for a V F.Hb Providence: substitutes an N for a K that normally projects intothe central cavity of the tetramer Of the above, which do youexpect to be: LEAST likely to cause pathological symptoms. MOSTlikely to show pI values different from that of HbA on anisoelectric focusing gel. MOST likely to show an increase in theoverall affinity of the hemoglobin for oxygen. EXPLAIN youranswers.
