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Cystic fibrosis (CF) is caused by a genetic mutation resulting in defective proteins in secretory cells,...

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Biology

Cystic fibrosis (CF) is caused by a genetic mutation resultingin defective proteins in secretory cells, mainly in the epitheliallining of the respiratory tract. The one in every 2,000 Caucasianbabies who has the disease is homozygous for the recessive mutant.Although medical treatment is becoming more effective, in the past,most children with CF died before their teens. About 20 Caucasianin 2,000 are carriers of the trait, having one mutant and onenormal allele, but they do not develop the disease. According torules of population genetics, the frequency of the homozygousrecessive genotype should be rarer than it is. What is one possibleexplanation for the unusually high frequency of this allele inCaucasian population?

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There are three major factor that causes an unusually high frequency for a lethal recessive allelle The first and the most important is heterozygote advantage to Tuberculosis which    See Answer
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