Cytosolic Ca2+ is an important “second messengerâ€, and is
usually maintained at sub-micromolar concentrations. List 3
distinct...
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Biology
Cytosolic Ca2+ is an important “second messengerâ€, and isusually maintained at sub-micromolar concentrations. List 3distinct mechanisms through which the cytosolic concentration ofCa2+ is regulated.
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Calcium is a ubiquitous second messenger with wideranging physiological roles These include muscle contraction neuronal transmission as in an excitatory synapse cellular motility including the movement of flagella and cilia fertilization cell growth proliferation neurogenesis learning and memory as with synaptic plasticity and secretion of saliva 3 distinct mechanisms are as follows 1Muscle Contractions Contractions of skeletal muscle fiber are caused due to electrical stimulation This process is caused by the depolarization of the transverse tubular junctions Once depolarized the sarcoplasmic reticulm SR releases Ca2 into the myoplasm where it will bind to a number of calcium sensitive buffers The Ca2 in the myoplasm will diffuse to Ca2 regulator sites on the thin filaments This leads to the actual contraction of the muscle Contractions of smooth muscle fiber are dependent on how a Ca2 influx
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