describe how phase I and phase II metabolism influence/affect i)
renal and ii) hepatic elimination
of a...
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Biology
describe how phase I and phase II metabolism influence/affect i)renal and ii) hepatic eliminationof a drug? Answers must be detailed and complete sentences.
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Drug elimination is the process of removing administered drugs from the body Hydrophilic drugs can directly undergo excretion while hydrophobic drugs need to undergo certain metabolic modifications in their molecules Generally the liver is responsible for drug metabolism and kidney for excretion so dysfunction at any level can lead to the accumulation of drug toxic metabolites Biotransformation of hydrophobic drugs along with increasing the hydrophilicity also detoxifies the exogenous substances 2 pathways of hepatic drug transformation are phase I and phase II Phase I Hepatic microsomal enzymes cause oxidation reduction and
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