Describe the principles of
immunocytochemistry/immunohistochemistry and how the technique can
be usefully employed in the diagnosis and...
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Chemistry
Describe the principles ofimmunocytochemistry/immunohistochemistry and how the technique canbe usefully employed in the diagnosis and classification oftumours
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Principles of immunohistochemistry The principle of IHC has existed since the 1930s but it was not until 1941 that the first IHC study was reportedCoons and his colleagues used Fluorescein isothiocyanate FITClabeled antibodies with a fluorescent dye to localize pneumococcal antigens in infected tissues With the expansion and development of IHC technique enzyme labels have been introduced such as peroxidase89 and alkaline phosphatase Colloidal gold label has also been discovered and used to identify immunohistochemical reactions at both light and electron microscopy levels Other labels include radioactive elements and the immunoreaction can be visualized by autoradiography The aim of IHC is to perform most IHC staining by causing
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