Describe the role of APC/C in progression through the
metaphase-to-anaphase transition. Be sure to include in...
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Biology
Describe the role of APC/C in progression through themetaphase-to-anaphase transition. Be sure to include in youranswer:a) What exactly does APC/C do enzymatically?b) How does itinteract with cyclin and securing?c) The roles of separase andCdc20
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The anaphasepromoting complex APCC is an RING finger E3ubiquitin ligase involved in metaphase to anaphase transition It targets proteins for degradation by the 26S proteasomal pathways APCC catalyzes the last step of the cascade that is involved in ubiquitinylation of substrates E1 E2 and E3 enzymes are involved in ubiquitinylation E1 enzyme is an ubiquitinactivating enzyme E1 can bins ubiquitin which is then transferred to the E2 enzyme E2 along with E3 will transfer ubiquitin to lysine residue on target protein APCC is E3 ligase
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