Logo
Home Study Material Contact Search
AI Chat FREE
  1. sciences
  2. biology
  3. describe three different lead discovery approaches

Describe three different lead discovery approaches (other than rational)!? And how would you discover a lead by...

50.1K

Verified Solution

Question

Biology

Describe three different lead discovery approaches(other than rational)!?

And how would you discover a lead by a rationalapproach?

Answer & Explanation Solved by verified expert
4.4 Ratings (785 Votes)
Answer Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified by the process of drug discovery There are different approaches for lead discovery as follows 1 Traditional Library Screening The goal of screening of a library in whole or in part is to discover compounds with modest activity against a target The active compounds discovered through a screen are called hits Targets are normally enzymes or receptors so the term activity refers to an IC50 or EC50 value Compounds are normally stored as a stock solution and to be dispensed as needed by robotic equipment Dimethylsulfoxide DMSO is a preferred solvent The purity of compounds in the library is an important factor Reaction side products should be completely removed from a compound in a library Highthroughput screens involve some type of biochemical test for binding of the molecule of interest to a target The screens are done in 96 384 or 1536well microtiter plates As a library is screened small amounts of each member of the library will be placed in each well and tested for activity If each library member is a single compound a well will contain a single compound or a mixture of compounds    See Answer
Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:
  • Unlimited Question Access with detailed Answers
  • Zin AI - 3 Million Words
  • 10 Dall-E 3 Images
  • 20 Plot Generations
  • Conversation with Dialogue Memory
  • No Ads, Ever!
  • Access to Our Best AI Platform: Zin AI - Your personal assistant for all your inquiries!
Become a Member

Other questions asked by students

Q

a.) What is the thermal efficiency of a steam power plant operating on the Rankine cycle...

Mechanical Engineering
Q

Assume Jennifer is an office manager working at Acme LLC a local plumbing company. Jennifer has...

General Management
Q

y sin oot cos 2ot dy dt cosat 2wsin2wt d y y Oscillatory but S...

Physics
Q

Change the equation to slope - intercept form (y = mx + b) and show...

Basic Math
Q

Newly formed S&J Iron Corporation has 101,000 shares of $3 par common stock...

Accounting
Q

The BRS Corporation makes collections on sales according to the following schedule: 30% in month...

Accounting
Q

If one acre of land has twenty eight thousand two hundred and seventy individual plants...

Accounting
Q

Please answer with reason for all why the option is correct and why the other...

Accounting
Q

what are the legal requirements for equity crowdfunding and do you think that it is...

Accounting
Q

Alyeska Services Company, a division of a major oil company, provides various services to the...

Accounting
Q

Question 8 (8 points) An order for a metal fabrication requires production processes from two...

Finance
Q

Staff Company assigns Building Dept (BD) cost to line depts (P1 and P2) using floor...

Accounting