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Differentiate between total ion chromatogram (TIC) and extracted ion chromatogram (EIC). Why quantification of analytes is...

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Chemistry

Differentiate between total ion chromatogram (TIC) and extractedion chromatogram (EIC). Why quantification of analytes is carriedout through integration of EIC?


Selected ion monitoring (SIM) is often used in determination ofanalytes at trace levels, (very low concentrations) provide a briefexplanation why one obtains lower detection lim-its with SIM thanSCAN.


Discuss the need for rapid scan or MIM data acquisition with massspectrometers when interfaced with chromatography techniques.

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Total ion current TIC chromatogram gives the sum of the masses of all the ions including those arising from the background over the entire range of masses being detected Extracted ion current EIC chromatogram gives all possible ions belonging to a particular mz value    See Answer
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