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Discuss all aspects of the LDL-R pathway – the receptor’s structure, interactions with the LDLs, the...

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Biology

Discuss all aspects of the LDL-R pathway – the receptor’sstructure, interactions with the LDLs, the structure of the LDLsand where made, their endocytosis, recycling of receptors, role ofpH – how let go of LDL, and fate of LDL within the cell.

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Answer Low density lipoprotein LDL receptors represents a group of structurally related transmembrane proteins that mediates the endocytosis of cholesterol rich LDL Low density lipoprotein lDL transports cholesterol from liver to peripheral tissues Its outer ssurface consists of a single layer of phospholipids and cholesterol in which the apoprotein apo B100 remains embedded Cholesterol is present in the inside non polar core LDL receptorss are present on all cells but most abundant in hepatic cells The LDL receptor is a polypeptide of 839 amino    See Answer
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