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1. Discuss the structural organization of lipoprotein particlessuch as HDL, LDL or VLDL. List all of the biomolecules found ineach and describe their function in the particle. How does theirstructure facilitate the function of the particles? What does eachdo? (9 points).

1. Find three diseases in humans where there is a metabolic defectthat results in an inability to process or metabolize specific
2. Lipids
3. Proteins or amino acids
4. Fats (lipids)

For each disease, explain the pathophysiology of the disease andthe symptoms that an individual with the disease experiences. (9points)

1. In the scientific literature, find a clinical trial that isprospective randomized as well as placebo-controlled. List thereference for the paper and explain the method of how thescientists randomized the trial and what the treatment groups were.Did the trial you found have any other features such as being acrossover trial or being blinded. (Extra credit is possible if youfind these additional features). (10 points)

1. Technetium 99m and fluorodeoxyglucose are two radioisotopesfrequently utilized in clinical medicine. Find two specificapplications (tests or treatments) for each and describe how theyare utilized. (8 points)

1. Describe how DNA is organized such that 46 chromosomes withapproximately 3 billion bases are able to fit in the limited spaceof the nucleus of a cell. In addition, how does transcriptionallyactive DNA differ from DNA that is not being transcribed? (6points)