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DNA mRNA OR 1 2 4 5 1 3 4 5 Ligand A Ligand B...

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Biology

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DNA mRNA OR 1 2 4 5 1 3 4 5 Ligand A Ligand B Protein Protein A Plasma Membrane Protein B Plasma Membrane Exon Intron 2nd Messenger Figure 1 Receptor proteins produced as a result of alternative splicing followed by activation of a second messenger 4 Cell signaling in eukaryotes is often dependent on receptor proteins located in the plasma membrane During the production of the mature mRNA molecules coding for these receptors pre mRNA molecules are processed to remove introns and to connect exons together The exons contain the sequences that code for proteins In certain instances different mature mRNA molecules can be formed from the same pre mRNA by alternative splicing which results in different protein sequences in the resulting polypeptides Figure 1 represents the expression of a gene with 5 exons that can be alternatively spliced to produce receptor protein A and receptor protein B a Explain how ligand A and ligand B can cause identical cellular responses in a cell b Predict the most likely effect of a two nucleotide deletion in the middle of the intron located between exc 4 and 5 on the structure of protein A Justify your prediction

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