esearch the role of molecular chaperones (note, we didn’t cover
this topic in class) and their...
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Biology
esearch the role of molecular chaperones (note, we didn’t coverthis topic in class) and their role in protein folding and provideme a summary of (a) how they work, (b) where they are found and (c)if there are any diseases that have been identified where theydon’t function appropriately.
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The role of molecular chaperons A large group of unrelated protein families helps to assist folding or unfloding of other macro molecular structure Folding of newly synthesized polypeptides in the crowded cellular environment requires the assistance of socalled molecular chaperone proteins the chaperons are primarily concerned with protein folding Role is to stabilize the unfolded proteins Unfold them for the translocation across the membrane or the degradation or to assist in their correct assembly They prevent inappropriate association of exposed hydrophobic surfaces and lead their substrate into productive folding Some chaperones are nonspecific and interact with a wide
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