Explain glomerular filtration and the mechanisms that control
its pressure and rate. Why is GFR critical...
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Medical Sciences
Explain glomerular filtration and the mechanisms that controlits pressure and rate. Why is GFR critical to normal urineformation?
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Glomerular filtration rate GFR is the rate of flow of blood and its filtration through the kidneys Blood flows into Bowmans capsule from where it enters the glomerular filtration apparatus via afferent arterioles Bowmans capsule covers the glomerulus and has visceral and parietal epithelial layers Visceral layer is made up of podocytes that allow fluid to enter the nephron via small slits This layer is present above the basement membrane Large molecules cannot pass through the visceral layers Nonfilterable larger molecules such as RBCs albumin leaves the kidneys via efferent arterioles 25 of the cardiac output enters the glomerulus which has a fenestrated epithelium fenestrated epithelium allows the movement of molecules less than 70nM size to pass through
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