Explain why any functional impairment of PDC, TCA cycle and
ETC/oxidative phosphorylation can cause lactic acidosis.
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Biology
Explain why any functional impairment of PDC, TCA cycle andETC/oxidative phosphorylation can cause lactic acidosis.
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The normal endpoint of anaerobic metabolism of glucose in the tissues is lactic acid The lactic acid exits the cells and transporte to the liver and oxidized back to pyruvic acid and finally converte to glucose and it is also known as Cori cycle Because of continual oxygen debt and buffering abilities of body lactic acidosis ensue REASON OF LACTIC ACIDOSIS DUE TO PDC Pyruvate dehydrogenase complex PDC deficiency caused due to low levels of enzymes that are nessessary for an chemical reaction that take place in the cells of the
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