Fill in the blank- During eukaryotic transcription, the assemblyof the general transcription factors begins with the binding of thefactor________in a complex with the general transcriptionfactor_________to DNA, causing a marked local distortion in thedouble helix. This factor binds at the DNA sequence calledthe________box, which is typically located 25 nucleotides upstreamfrom the transcription start site. Once RNA polymerase II has beenbrought to the promoter DNA, it must be released to begin makingtranscripts. This release process is facilitated by the addition ofphosphate groups to the tail of RNA polymerase by thefactor_______. General transcription factor and RNA polymerase arenot sufficient to efficiently initiate transcription in the celland are affected by proteins bound thousands of nucleotides awayfrom the promoter. Proteins that link distantly bound transcriptionregulators to RNA polymerase and the general transcription factorsinclude the large complex of proteins called the _________. Thepackaging of DNA into chromatin also affects transcriptionalinitiation, and histone________ is an enzyme that can render theDNA less accessible to the general transcription factors.
