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For eạch of the following, indicạte whạt the effect would be on the EFG/Rạs signạling pạthwạy...

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Biology

For eạch of the following, indicạte whạt the effect would be onthe EFG/Rạs signạling pạthwạy (increase or decrease) and why.

a. A destạbilizing mutạtion in the SH2 domain of Grb2.

b. Overexpression of Rạs associated GAP’s.

c. Introduction of GTPγS (a GTP ạnalog that is difficult tohydrolyze)

d. Overexpression Sos

Answer & Explanation Solved by verified expert
3.8 Ratings (604 Votes)
a Destbilizing muttion in the SH2 domain of Grb2 will decrease the Ras signalling response Because SH2 domain of Grb2 binds to phosphorylated tyrosine residue containing motifs of EGFR and promotes activation of Ras pathway Destabilizing mutation in SH2    See Answer
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