Hand draw the following transformations step by step, includingall intermediates. Ideally, also show electron pushing
A. Conversion of asparagine to aspartic and isoaspartic acid inpeptides.
B. Conversion of aspartic acid to isoaspartic acid inpeptides.
C. Cleavage of the peptide backbone at the aspartic acidresidue.
D. Discuss whether acid may catalyze each reaction (A, B or C);i.e., whether the reaction is faster at (pH lower than 7) than atpH 7.
E. Discuss whether base may catalyze each reaction (A, B or C);i.e., whether the reaction is faster at (pH higher than 7) than atpH 7.
