hi, trying to understand the proccess of crebs cycle..
a. If Isocitrate dehydrogenase is inhibited by axcess ofcitrate, and alpha ketogluterate by axcess of Suc-CoA, what exactlyhappeneds with the already made citrate and Suc-CoA? do they goback to being Acetyl coA and Alphaketogluterate respectively (andalso become into fatty acids, amino acids and purins)?
b. I also don't get how calcium signals for more production ofAcethyl coA? who gets this signal? is that the Icamsomthing...?
c. in HIF1 degradation in the proteosome, what exactly pVHL andPHD2 do? like what is done individually and what tougether?
d. does HIF1 stop crebs cycle? I only know it encouragesanaerobic respiration.. so what proccess does it stop if so? isdirectly or indirectly?
e. is there any other important substances in the crebs cycle? iremember something said about Fumarate and Succinate is theresomething worth remembering?
thanks in advance, I am very very lost and my summery is justconfusing me.
