How and where do many
DNA viruses such as SV40 replicate in the host cell?
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Biology
How and where do manyDNA viruses such as SV40 replicate in the host cell?
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Simian virus 40 Sv40 Belongs to polyoma viruses group The virus was first isolated as a contaminanat from a monkey kidney culutur used for the production of poliovirus vaccine Its genome is very small and can be easile modified for gene therapy purpose Its genome has ds circular DNA wrapped up as nucleosome with the help of histone proteins Viruses life cycles Virus binds to cell membrane and releases its DNA into host cell replicated transcribed and translated Makes proteins necessary to make protomeres New virions are produced lysislytic pathway Lysogeny no lysis incorporate viral DNA into host chromosome Eg Simian virus40 SV40 SV40 replication in host cell SV40 viruses are small 40nm diameter icosahedral nonenveloped viruses that replicate in the nucleus Depending on the host cell they can either transform the cell or replicate the virus and lyze the cell LYTIC CYCLE
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