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How can genetic linkage be used to map disease-associated loci? Use the identification of CFTR as the...

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Biology

How can genetic linkage be used to mapdisease-associated loci? Use the identification of CFTR asthe causative loci for CF via linkage analysis as an example inyour answer.

GWAS and linkage analysis are both used to mapdisease-associated loci. Compare and contrast the twotechniques.

Guys please help me with these two questions. They arelinked and Im struggling to find accurate answers.

Answer & Explanation Solved by verified expert
4.0 Ratings (678 Votes)
Linkage maps represent the genetic locations of loci on the chromosome They are constructed based on recombination frequency values Recombination frequency is directly proportional to the distance between two loci Greater the recombination frequency value greater is the distance between the two loci    See Answer
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