How do we get from a ligand binding to a heterotrimeric
GTP-binding protein to the activation...
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Biology
How do we get from a ligand binding to a heterotrimericGTP-binding protein to the activation of PKA?
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GPCR GProtein Coupled Binding receptors are a large family of transmembrane proteins They consist of seven transmembrane alphahelices with three extracellular and three intracellular loops On the extracellular surface of this receptor binds the ligand while on the intracellular surface is present the binding site for the GTPactivated protein Gprotein The structure of the Gprotein consists of three subunits alpha beta and gamma This Gprotein binds GDP at the alpha subunit in the inactive
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