i) Discuss the importin-alpha nuclear import cycle,mechanistically accounting for the key steps of nuclear transport.(Essay style include appropriate diagrams)
ii) Quantitative reasoning, 10 marks: During DNA replication,the genome is duplicated as chromatin. How fast does nucleartransport of histones have to take place in terms ofmolecules/pore/second in order to support S-phase in human cells?Assume the genome is 6 x 109 bp, a nucleosome spans 200 bp and that75% of the genome is replicated in the first 3 hr of S-phase.Nuclei contain 2000 nuclear pore complexes. (showwork)
