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I have sequenced roughly 24 genomes from two different continents (Africa and South America), specifically for...

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Biology

I have sequenced roughly 24 genomes from two differentcontinents (Africa and South America), specifically for theenvelope gene of yellow fever virus. I used software to generatethe dN and dS ratio for each continent

Africa: (dS= 0.2065, dN= 0.0031.) dN/dS ratio= 0.0150

South America: (dS=0.5541, dN= 0.0112.) dN/dS ratio= 0.0202

Im unsure how to interpret these ratio's, and how the differencein the two suggests any differences in the type of selection forthe enveloped protein in each continent.

Answer & Explanation Solved by verified expert
3.8 Ratings (437 Votes)
Nucleotide substitutions in genes coding for proteins can be silent synonymous substitution that do not change the amino acid or nonsynonymous substitution that change the amino acid Usually selection removes nonsynonymous substitution However under certain Darwanian conditions they may be retained Studying number of these synonymous and nonsynonymous substitutions indicates degree of selection pressure of a system Synonymous substitutions give the evolutionary distance between two sequences Nonsynonymous substitutions can be due to    See Answer
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